The perirhinal cortex in the dog’s brain is composed of two traditional Brodmann’s areas: 35 and 36. Area 35 is situated along the entire rostro-caudal extent of the fundus of the posterior rhinal sulcus, whereas area 36 occupies its lateral bank. In this study, four subdivisions were distinguished in area 35 based on cytoarchitectonic differentiation. Area 36 is poorly developed in the dog’s brain and was divided into two subdivisions. The most characteristic features of area 35 are: a wide layer I, scattered cell clusters in layer II, and a prominent layer V containing a distinct population of large multiform neurons. Area 36 can be recognized by the presence of numerous cell clusters in layer II and increasing radial arrangement of neurons in deep layers of the area. Two fields of the postrhinal cortex were identified in the additional postrhinal gyrus, which is found in the fundus of the most caudal extent of the posterior rhinal sulcus.
Agnieszka WoŸnicka and Anna Kosmal
Cytoarchitecture of the canine perirhinal and postrhinal cortex.
Acta Neurobiol. Exp. 2003, 63: 197-209.
http://www.nencki.gov.pl/pdf/an/vol63/woznicka.pdf
Monday, December 31, 2007
Response Differences in Monkey TE and Perirhinal Cortex: Stimulus Association Related to Reward Schedules
Anatomic and behavioral evidence shows that TE and perirhinal cortices are two
directly connected but distinct inferior temporal areas. Despite this distinctness, physiological properties of neurons in these two areas generally have been similar with neurons in both areas showing selectivity for complex visual patterns and showing response modulations
related to behavioral context in the sequential delayed matchto-sample (DMS) trials, attention, and stimulus familiarity. Here we identify physiological differences in the neuronal activity of these two areas. We recorded single neurons from area TE and perirhinal cortex while the monkeys performed a simple behavioral task using randomly interleaved visually cued reward schedules of one, two, or three DMS trials. The monkeys used the cue’s relation to the reward schedule (indicated by the brightness) to adjust their behavioral performance. They performed most quickly and most accurately in trials in which reward was immediately forthcoming and progressively less well as more intermediate trials remained. Thus the monkeys appeared more motivated as they progressed through the trial schedule. Neurons in both TE and perirhinal cortex responded to both the visual cues related to the reward schedules and the stimulus patterns used in the DMS trials. As expected, neurons in both areas showed response selectivity to the DMS patterns, and significant, but small, modulations related to the behavioral context in the DMS trial. However, TE and perirhinal neurons showed strikingly different response properties. The latency distribution of perirhinal responses was centered 66 ms later than the distribution of TE responses, a larger difference than the 10–15 ms usually found in sequentially connected visual cortical areas. In TE, cue-related responses were related to the cue’s brightness. In perirhinal cortex, cue-related responses were related to the trial schedules independently of the cue’s brightness. For example, some perirhinal neurons responded in the first trial of any reward schedule including the one trial schedule, whereas other neurons
failed to respond in the first trial but respond in the last trial of any schedule. The majority of perirhinal neurons had more complicated relations to the schedule. The cue-related activity of TE neurons is interpreted most parsimoniously as a response to the stimulus brightness,
whereas the cue-related activity of perirhinal neurons is interpreted most parsimoniously as carrying associative information about the animal’s progress through the reward schedule. Perirhinal cortex may be part of a system gauging the relation between work schedules
and rewards.
Liu, Zheng and Barry J. Richmond.
Response differences in monkey TE and perirhinal cortex: stimulus association related to reward schedules.
J. Neurophysiol. 83: 1677–1692, 2000.
http://neuron.nimh.nih.gov/richmond/docs/TE_perirhinal_reward_schedules.pdf
directly connected but distinct inferior temporal areas. Despite this distinctness, physiological properties of neurons in these two areas generally have been similar with neurons in both areas showing selectivity for complex visual patterns and showing response modulations
related to behavioral context in the sequential delayed matchto-sample (DMS) trials, attention, and stimulus familiarity. Here we identify physiological differences in the neuronal activity of these two areas. We recorded single neurons from area TE and perirhinal cortex while the monkeys performed a simple behavioral task using randomly interleaved visually cued reward schedules of one, two, or three DMS trials. The monkeys used the cue’s relation to the reward schedule (indicated by the brightness) to adjust their behavioral performance. They performed most quickly and most accurately in trials in which reward was immediately forthcoming and progressively less well as more intermediate trials remained. Thus the monkeys appeared more motivated as they progressed through the trial schedule. Neurons in both TE and perirhinal cortex responded to both the visual cues related to the reward schedules and the stimulus patterns used in the DMS trials. As expected, neurons in both areas showed response selectivity to the DMS patterns, and significant, but small, modulations related to the behavioral context in the DMS trial. However, TE and perirhinal neurons showed strikingly different response properties. The latency distribution of perirhinal responses was centered 66 ms later than the distribution of TE responses, a larger difference than the 10–15 ms usually found in sequentially connected visual cortical areas. In TE, cue-related responses were related to the cue’s brightness. In perirhinal cortex, cue-related responses were related to the trial schedules independently of the cue’s brightness. For example, some perirhinal neurons responded in the first trial of any reward schedule including the one trial schedule, whereas other neurons
failed to respond in the first trial but respond in the last trial of any schedule. The majority of perirhinal neurons had more complicated relations to the schedule. The cue-related activity of TE neurons is interpreted most parsimoniously as a response to the stimulus brightness,
whereas the cue-related activity of perirhinal neurons is interpreted most parsimoniously as carrying associative information about the animal’s progress through the reward schedule. Perirhinal cortex may be part of a system gauging the relation between work schedules
and rewards.
Liu, Zheng and Barry J. Richmond.
Response differences in monkey TE and perirhinal cortex: stimulus association related to reward schedules.
J. Neurophysiol. 83: 1677–1692, 2000.
http://neuron.nimh.nih.gov/richmond/docs/TE_perirhinal_reward_schedules.pdf
Collateral projection from the amygdalo–hippocampal transition area and CA1 to the hypothalamus and medial prefrontal cortex in the rat
Amygdaloid and hippocampal neurons projecting to both the medial prefrontal cortex and hypothalamus by way of axon collaterals were examined in the rat by double labeling method using fluorescence retrograde tracers. Fluoro-gold was injected in the medial prefrontal cortex, while Fluoro-red was injected into the ventromedial and ventral premammillary nuclei of the hypothalamus. The results indicated that neurons which sent axon collaterals to both the medial prefrontal cortex and hypothalamus constituted 50 or 30% of populations of medial prefrontal cortex-projecting neurons in the amygdalo–hippocampal transition area or in CA1, respectively. Possible roles of the neurons with axon collaterals in sexually related aggressive and/or defensive behavior were discussed.
Tanemichi Chiba
Collateral projection from the amygdalo–hippocampal transition area and CA1 to the hypothalamus and medial prefrontal cortex in the rat.
Neuroscience Research Volume 38, Issue 4, December 2000, Pages 373-383.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0H-426XXND-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7dfba4ddd462ea5905d7bef0ad3ecea4
Tanemichi Chiba
Collateral projection from the amygdalo–hippocampal transition area and CA1 to the hypothalamus and medial prefrontal cortex in the rat.
Neuroscience Research Volume 38, Issue 4, December 2000, Pages 373-383.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0H-426XXND-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7dfba4ddd462ea5905d7bef0ad3ecea4
Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the ...
A combination of anterograde and retrograde tracing techniques was used to study the projections to the nucleus accumbens from the amygdala, the hippocampal formation (including the entorhinal cortex), and the perirhinal cortex in two species of macaque monkey. To help identify possible subregions within the nucleus accumbens, the distribution of calbindin was examined in two additional monkeys. Although this revealed evidence of core- and shell-like regions within the accumbens, these different regions could not consistently be related to cytoarchitectonic features. The rostral amygdala sent nearly equivalent projections to both the medial and the lateral portions of nucleus accumbens, whereas projections arising from the middle and caudal amygdala terminated preferentially in the medial division of nucleus accumbens. The basal nucleus was the major source of these amygdala efferents, and there was a crude topography as parts of the basal and accessory basal nuclei terminated in different parts of nucleus accumbens. The subiculum was the major source of hippocampal projections to the nucleus accumbens, but some hippocampal efferents also originated in the parasubiculum, the prosubiculum, the adjacent portion of CA1, and the uncal portion of CA3. These hippocampal projections, which coursed through the fornix, showed a rostrocaudal gradient as more arose in the rostral hippocampus. Hippocampal efferents terminated most densely in the medial and ventral portions of nucleus accumbens, along with light label in the adjacent olfactory tubercle. The entorhinal projections were more evenly distributed between the medial nucleus accumbens and the olfactory tubercle, whereas the perirhinal projections were primarily to the olfactory tubercle. These cortical inputs were less reliant on the fornix. Amygdala and subicular (hippocampal) projections overlapped most completely in the medial division of nucleus accumbens.
David P. Friedman, John P. Aggleton, Richard C. Saunders.
Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the Macaque brain.
J. Comp. Neurol. 450:345-365, 2002.
http://www3.interscience.wiley.com/cgi-bin/abstract/97515953/
David P. Friedman, John P. Aggleton, Richard C. Saunders.
Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the Macaque brain.
J. Comp. Neurol. 450:345-365, 2002.
http://www3.interscience.wiley.com/cgi-bin/abstract/97515953/
An extrahippocampal projection from the dentate gyrus to the olfactory tubercle
Background:
The dentate gyrus is well known for its mossy fiber projection to the hippocampal field 3 (CA3) and its extensive associational and commissural connections. The dentate gyrus, on the other hand, has only few projections to the CA1 and the subiculum, and none have clearly been shown to extrahippocampal target regions.Results:
Using anterograde and retrograde tracer techniques in the Madagascan lesser hedgehog tenrec (Afrosoricidae, Afrotheria) it was shown in this study that the dentate hilar region gave rise to a faint, but distinct, bilateral projection to the most rostromedial portion of the olfactory tubercle, particularly its molecular layer. Unlike the CA1 and the subiculum the dentate gyrus did not project to the accumbens nucleus. A control injection into the medial septum-diagonal band complex also retrogradely labeled cells in the dentate hilus, but these neurons were found immediately adjacent to the heavily labeled CA3, while the tracer injections into the rostromedial tubercle did not reveal any labeling in CA3.Conclusion:
The dentate hilar neurons projecting to the olfactory tubercle cannot be considered displaced cells of CA3 but represent true dentato-tubercular projection neurons. This projection supplements the subiculo-tubercular projection. Both terminal fields overlap among one another as well as with the fiber terminations arising in the anteromedial frontal cortex. The rostromedial olfactory tubercle might represent a distinct ventral striatal target area worth investigating in studies of the parallel processing of cortico-limbic information in tenrec as well as in cat and monkey.
Figure 3
Retrograde labeling in DtHi and HCt following tracer injections into the olfactory tubercle. Tracer injections into the rostromedial Tu (A) consistently labeled a few dentate hilar neurons (D-H; arrows point to labeled cells), but failed to label the CA3 (D-F). A-E are from Et03-58W, F-H from Et01-47W. Some labeled neurons are also noted in the ipsilateral, anterior HCt (B, C) confirming previous anterograde data [28]. Remarkably, both the HCt and the DtHi project to the rostromedial Tu, but not to the Acb. Arrow heads point to similar location. OfB, olfactory bulb; PCx, paleocortex. Scale bars = 0.8 mm in A, 0.4 mm in B and D, 0.3 mm in F, 0.2 mm in C, E and H (as G).
Heinz Künzle.
An extrahippocampal projection from the dentate gyrus to the olfactory tubercle.
BMC Neurosci. 2005; 6: 38.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1180450&rendertype=figure&id=F3
Sunday, December 30, 2007
The Orbitofrontal Cortex and Reward
The primate orbitofrontal cortex contains the secondary taste cortex, in which the reward value of taste is represented. It also contains the secondary and tertiary olfactory cortical areas, in which information about the identity and also about the reward value of odors is represented. The orbitofrontal cortex also receives information about the sight of objects and faces from the temporal lobe cortical visual areas, and neurons in it learn and reverse the visual stimulus to which they respond when the association of the visual stimulus with a primary reinforcing stimulus (such as a taste reward) is reversed. However, the orbitofrontal cortex is involved in representing negative reinforcers (punishers) too, such as aversive taste, and in rapid stimulus–reinforcement association learning for both positive and negative primary reinforcers. In complementary neuroimaging studies in humans it is being found that areas of the orbitofrontal cortex (and connected subgenual cingulate cortex) are activated by pleasant touch, by painful touch, by rewarding and aversive taste, and by odor. Damage to the orbitofrontal cortex in humans can impair the learning and reversal of stimulus– reinforcement associations, and thus the correction of behavioral responses when these are no longer appropriate because previous reinforcement contingencies change. This evidence thus shows that the orbitofrontal cortex is involved in decoding and representing some primary reinforcers such as taste and touch; in learning and reversing associations of visual and other stimuli to these primary reinforcers; and in controlling and correcting reward-related and punishment-related behavior, and thus in emotion.
Figure 1. Schematic diagram showing some of the gustatory, olfactory, visual and somatosensory pathways to the orbitofrontal cortex, and some of the outputs of the orbitofrontal cortex. The secondary taste cortex and the secondary olfactory cortex are within the orbitofrontal cortex. V1, primary visual cortex. V4, visual cortical area V4. Abbreviations: as, arcuate sulcus; cc, corpus callosum; cf, calcarine fissure; cgs, cingulate sulcus; cs, central sulcus; ls, lunate sulcus; ios, inferior occipital sulcus; mos, medial orbital sulcus; os, orbital sulcus; ots, occipito-temporal sulcus; ps, principal sulcus; rhs, rhinal sulcus; sts, superior temporal sulcus; lf, lateral (or Sylvian) fissure (which has been opened to reveal the insula); A, amygdala; INS, insula; T, thalamus; TE (21), inferior temporal visual cortex; TA (22), superior temporal auditory association cortex; TF and TH, parahippocampal cortex; TG, temporal pole cortex; 12, 13, 11, orbitofrontal cortex; 35, perirhinal cortex; 51, olfactory (prepyriform and periamygdaloid) cortex. Most of the forward projections shown in this diagram have corresponding backprojections (Rolls and Treves, 1998).
Edmund T. Rolls
The Orbitofrontal Cortex and Reward
Cereb. Cortex 10: 284-294.
Figure 1. Schematic diagram showing some of the gustatory, olfactory, visual and somatosensory pathways to the orbitofrontal cortex, and some of the outputs of the orbitofrontal cortex. The secondary taste cortex and the secondary olfactory cortex are within the orbitofrontal cortex. V1, primary visual cortex. V4, visual cortical area V4. Abbreviations: as, arcuate sulcus; cc, corpus callosum; cf, calcarine fissure; cgs, cingulate sulcus; cs, central sulcus; ls, lunate sulcus; ios, inferior occipital sulcus; mos, medial orbital sulcus; os, orbital sulcus; ots, occipito-temporal sulcus; ps, principal sulcus; rhs, rhinal sulcus; sts, superior temporal sulcus; lf, lateral (or Sylvian) fissure (which has been opened to reveal the insula); A, amygdala; INS, insula; T, thalamus; TE (21), inferior temporal visual cortex; TA (22), superior temporal auditory association cortex; TF and TH, parahippocampal cortex; TG, temporal pole cortex; 12, 13, 11, orbitofrontal cortex; 35, perirhinal cortex; 51, olfactory (prepyriform and periamygdaloid) cortex. Most of the forward projections shown in this diagram have corresponding backprojections (Rolls and Treves, 1998).
Edmund T. Rolls
The Orbitofrontal Cortex and Reward
Cereb. Cortex 10: 284-294.
Neurogenesis in adult dentate gyrus: Evidence of mitosis in differentiated granule cells following spatial learning
An increasing body of evidence has been presented to demonstrate the idea that neurogenesis occurs only during development and ends before puberty is erroneous. In adult vertebrate brain, neurogenesis persists throughout life mainly in two discrete regions – the dentate gyrus of the hippocampus (DG) and the olfactory bulb. Neurogenesis has been shown by detection of tagged thymidine analogues which are incorporated into the S phase of the cell cycle, but these
may also detect repaired DNA in post-mitotic neurons and/or an abortive cell cycle. Recent retroviral labelling has shown that neuronal progenitors/neuroblasts divide and produce functional neurons. However, it is unclear whether differentiated granule cells (GC) in the DG can divide and give rise to another GC. We have used three-dimensional (3D) reconstructions of serial ultrathin sections to identify and reconstruct GC, thereby illustrating individual mitotic elements and phases. We report that functional GC with clear synaptic specializations re-enter the cell cycle demonstrating for the first time that newly generated neurons within the DG can arise not only from stem cell precursors, but also from differentiated GC.
Neurogenesis in adult dentate gyrus: Evidence of mitosis in differentiated granule cells following spatial learning
V.Popov, J.J.Rodriguez, H.A.Davies, I.V.Kraev, D.Banks, M.I.Cordero, C.Sandi and M.G.Stewart
18TH NATIONAL MEETING OF THE BRITISH NEUROSCIENCE ASSOCIATION 2005
may also detect repaired DNA in post-mitotic neurons and/or an abortive cell cycle. Recent retroviral labelling has shown that neuronal progenitors/neuroblasts divide and produce functional neurons. However, it is unclear whether differentiated granule cells (GC) in the DG can divide and give rise to another GC. We have used three-dimensional (3D) reconstructions of serial ultrathin sections to identify and reconstruct GC, thereby illustrating individual mitotic elements and phases. We report that functional GC with clear synaptic specializations re-enter the cell cycle demonstrating for the first time that newly generated neurons within the DG can arise not only from stem cell precursors, but also from differentiated GC.
Neurogenesis in adult dentate gyrus: Evidence of mitosis in differentiated granule cells following spatial learning
V.Popov, J.J.Rodriguez, H.A.Davies, I.V.Kraev, D.Banks, M.I.Cordero, C.Sandi and M.G.Stewart
18TH NATIONAL MEETING OF THE BRITISH NEUROSCIENCE ASSOCIATION 2005
Subscribe to:
Posts (Atom)
